Changes in Liver Function During Experimentally Induced Human Hepatitis *

Recently the production of infectious hepatitis and homologous serum jaundtice in human volunteers afforded an unusual opportunity to study changes in hepatic function during this disease.3" This study permitted initial control measurements of liver function to be made before inoculation with icterogenic material. Changes in liver function occurring during the disease could also be followed until normal conditions were restored, so that a complete sequence of events was obtained. These studies of liver function during infectious hepatitis are of interest, first, as an experimental control for comparison with the large amount of work on spontaneous infectious hepatitis, and second, under the above conditions liver function tests were performed at fairly close intervals over an.extended period and are of interest in a comparison of different liver function tests. The results of these functional tests are reported in detail. Discussion of the large amount of literature in this field is withheld, as a large amount of work on spontaneous infectious hepatitis and homologous serum jaundice is yet to be reported by others.